POLYMORPHISM OF DNA MISMATCH REPAIR GENES IN ENDOMETRIAL CANCER

Polymorphism of DNA mismatch repair genes in endometrial cancer.

UNLABELLED Endometrial cancer (EC) is the second most common malignancy associated with hereditary non-polyposis colorectal cancer (HNPCC) family. The development of HNPCC is associated with defects in DNA mismatch repair (MMR) pathway resulting in microsatellite instability (MSI). MSI is present in a greater number of EC than can be accounted for by inherited MMR mutations, therefore alternati...

DNA Mismatch Repair (MMR) Genes and Endometrial Cancer

DNA mismatch repair genes and colorectal cancer.

Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer

Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to ...

Epimutation in DNA Mismatch Repair (MMR) Genes